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') | Skip to Main Content Advertisement Close Blood Blood Advances Hematology ASH-SAP ASH Clinical News The Hematologist International Blood Chinese Edition Blood Japanese Edition Blood Italian Edition Blood Latin America Edition Blood Spanish Edition ASH ASH Home Research Education Advocacy Meetings Publications ASH Store Cart User Tools Cart Sign In Language foreach (var lang in Model.LanguageOptions) { string selectedClass = (lang.SiteId == Model.SiteId ? " selected" : ""); Html.Raw(String.Format(" {2} ", selectedClass, lang.SiteUrl, lang.LanguageText)) ; } -- Search search input Search input auto suggest search filter All Content All Journals Blood Search Toggle Menu Menu Issues Current Issue All Issues First edition Abstracts 2019 Annual Meeting 2019 Late Breaking 2018 Annual Meeting 2017 Annual Meeting All Meeting Abstracts Collections Collections Special Collections Multimedia Alerts Author Center Submit Author Guide Style Guide Why Submit to Blood? About About Blood Editorial Board and Staff Subscriptions Public Access Copyright Alerts Blood Classifieds Current Issue Volume 135 , Issue 26 , June 25, 2020 View This Issue About The Journal About The Journal Blood is a weekly medical journal published by the American Society of Hematology. It was founded by Dr. William Dameshek, the researcher credited with describing the concept of myeloproliferative diseases and participating in the first studies of nitrogen mustard in various blood malignancies, in 1946, and has since been in continuous publication. Issue Highlights Dissecting the molecular pathogenesis of blast crisis of CML Excellent survival of stage I-II nodular lymphocyte-predominant Hodgkin lymphoma Dysplasia and clonal hematopoiesis in newly diagnosed multiple myeloma Impact of genetic markers on response to obinutuzumab/venetoclax in untreated CLL HLA determinants contributing to immune TTP How I Treat: safely treating pain in hematologic malignancies with opioid therapy Blood Podcast, Episode 26 Latest in Blood Free Articles Hemophagocytic syndrome–associated intravascular large B-cell lymphoma Kaleigh E. Lindholm; Mark D. Ewalt DOI: 10.1182/blood.2020005434 View All Free Articles Plenary Papers An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia Tun Kiat Ko; Asif Javed; Kian Leong Lee; Thushangi N. Pathiraja; Xingliang Liu; Simeen Malik; Sheila Xinxuan Soh; Xiu Ting Heng; Naoto Takahashi; Joanna H. J. Tan; Ravi Bhatia; Alexis J. Khng; Wee-Joo Chng; Yee Yen Sia; David A. Fruman; King Pan Ng; Zhu En Chan; Kim Jiajing Xie; Qiangze Hoi; Cheryl Xueli Chan; Audrey S. M. Teo; Oscar Velazquez Camacho; Wee Yang Meah; Chiea Chuen Khor; Chin Thing J. Ong; Wei Jia W. Soon; Patrick Tan; Pauline C. Ng; Charles Chuah; Axel M. Hillmer; S. Tiong Ong DOI: 10.1182/blood.2020004834 View All Plenary Papers First Edition Interleukin-18 and cytotoxic impairment are independent and synergistic causes of murine virus-induced hyperinflammation Paul Tsoukas; Emily Rapp; Lauren Van Der Kraak; Eric S Weiss; Vinh Dang; Corinne Schneider; Edwin Klein; Jennifer Picarsic; Rosalba Salcedo; Charles Andrew Stewart; Scott Canna DOI: 10.1182/blood.2019003846 View All First Edition Articles Clinical Trials and Observations Early response observed in pediatric patients with relapsed/refractory Burkitt lymphoma treated with chimeric antigen receptor T cells Wenqun Zhang; Jing Yang; Chunju Zhou; Bo Hu; Ling Jin; Biping Deng; Yang Liu; Shan Wang; Alex H. Chang; Juan Du; Zifen Gao; Yonghong Zhang DOI: 10.1182/blood.2019002008 View All Clinical Trials and Observations Advertisement Message from ASH President on Diversity, Equity, and Inclusion Authors and Reviewers: New COVID-19 Announcement Featured Content Blood Podcast: Season 1, Episode 26 In this week’s episode we’ll examine the cause and clinical significance of dysplastic hematopoiesis at time of diagnosis in patients with multiple myeloma, review a multi‐omics analysis of patients that have undergone blastic transformation of chronic myeloid leukemia, and learn about HLA alleles that are either risk factors or protective for immune-mediated TTP in Japan. An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia In a study reported in this Plenary Paper, Ko et al used a multi-“omic” analysis of paired chronic phase and blast crisis (BC) chronic myeloid leukemia samples to demonstrate strikingly convergent patterns of gene expression underlying BC. Diverse genetic changes occurring with progression converged on modifications of the polycomb repressor complex that induce epigenetic changes, favoring stem cell proliferation and survival at the expense of differentiation. Stage I-II nodular lymphocyte-predominant Hodgkin lymphoma: a multi-institutional study of adult patients by ILROG Schöder and colleagues report the results of an imaging substudy within a randomized trial of R-CHOP or dose-adjusted-EPOCH-R for de novo diffuse large B-cell lymphoma. In this carefully conducted study, interim positron emission tomography after 2 cycles of treatment had predictive value only when the percent change in tracer uptake was calculated, not when the standard visual 5-point scale was used. Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax Tausch et al assessed the prognostic impact of IGHV mutational status and genomic mutations in chronic lymphocytic leukemia (CLL) for treatment-naïve patients in a trial comparing obinutuzumab and chlorambucil (GClb) vs obinutuzumab and venetoclax (VenG). With the exception of del(17p), mutations associated with decreased progression free survival (PFS) with GClb treatment do not confer worse PFS upon treatment with VenG. Biological and clinical significance of dysplastic hematopoiesis in patients with newly diagnosed multiple myeloma Maia et al prospectively analyzed marrow biopsies of 285 newly diagnosed multiple myeloma patients for flow and DNA evidence of dysplastic hematopoiesis, revealing 33 patients with evidence of dysplasia, half with clonal hematopoiesis (CH). CH was independently associated with inferior survival in this group and in a retrospective analysis including over 1000 patients on previous protocols. HLA loci predisposing to immune TTP in Japanese: potential role of the shared ADAMTS13 peptide bound to different HLA-DR HLA loci predisposing to immune thrombotic thrombocytopenic purpura (TTP) in the white population have been described. In this study, analysis of the HLA haplotypes in 52 Japanese immune TTP patients identifies a different predisposing haplotype from that in whites. Interestingly, modeling different predisposing DRB1 alleles in the Japanese and white populations predicts binding to the same ADAMTS13 peptide. Advertisement Current Issue First edition All Issues Collections Abstracts Authors Submit to Blood About Blood Subscriptions Public Access Permissions Alerts Contact Us Institutions/Librarians Blood Classifieds Advertising in Blood Terms and Conditions Twitter American Society of Hematology 2021 L Street NW, Suite 900 Washington, DC 20036 TEL +1 202-776-0544 FAX +1 202-776-0545 ASH Publications Blood Blood Advances Hematology, ASH Education Program ASH Clinical News ASH-SAP The Hematologist American Society of Hematology ASH Home Research Education Advocacy Meetings Publications ASH Store Copyright ©2020 by American Society of Hematology Privacy Policy Cookie Policy Terms of Use Contact Us Close Modal This Feature Is Available To Subscribers Only Sign In or Create an Account Close Modal Close Modal Advertisement X...